Safety & toxicology
Toxicology
Safety studies evaluating acute and longer-term effects, including toxicity, irritation and sensitisation, to support product safety and regulatory assessment
- Key capability
- Multi-year
- Listed methods
- 19
- Instruments
- 6
Overview
Toxicology, in overview.
Discipline group
Safety & toxicology
Capability groups
4
Toxicology is the division the rest of the laboratory is built around. It runs under GLP certification, operates multiple vivaria, and is staffed by toxicologists holding DABT credentials — the board certification that regulators outside India look for first.
The work spans the full duration axis. Acute studies resolve in days; subchronic and chronic programmes run for months; carcinogenicity bioassays run for years without a gap in the record. Multiple state-of-the-art inhalation chambers let us run inhalation toxicity studies on small animals, which is essential for evaluating airborne chemicals and inhaled drug products.
Trace-level analytical support sits inside the division rather than beside it. LC-MS/MS, ICP-MS and GC-MS detect chemicals at the concentrations that matter for dose confirmation and tissue distribution, and a High-Throughput Screening platform front-loads the decisions that would otherwise cost a full study to answer.
Capabilities
Four capability groups. 19 listed methods.
Our toxicology capabilities support studies across different exposure routes and durations. Study designs are tailored to the test item, intended use and relevant guidelines, with documented procedures supporting sample traceability, data review and archiving.
General toxicology
9 methods
- Acute oral, dermal and inhalation toxicity
- Subchronic and chronic toxicity
- NOEL and NOAEL determination
- Developmental and reproductive toxicity
- Carcinogenicity
- Immunotoxicity
- Neurotoxicity
- Endocrine disruption studies
- Histopathological examination
Dermal toxicology
4 methods
- Acute dermal toxicity
- Skin sensitisation — LLNA and GPMT
- Skin irritation and corrosion
- Dermal penetration studies
Inhalation toxicology
4 methods
- Acute inhalation toxicity
- Respiratory sensitisation
- Lung function assessment
- Histopathological examination
Systemic toxicity
2 methods
- Assessment of toxicity in the liver, kidneys, lungs and heart
- Specialised staining techniques
Specifications
On the record.
Guideline numbers, test species and instrument names are reproduced exactly as the laboratory publishes them, because a method is only portable across borders if it can be named precisely.
Instrument estate
6 platforms- 01Liquid chromatography–tandem mass spectrometry (LC-MS/MS)
- 02Inductively coupled plasma mass spectrometry (ICP-MS)
- 03Gas chromatography–mass spectrometry (GC-MS)
- 04High-Throughput Screening (HTS) platform
- 05Multiple inhalation chambers
- 06Advanced microscopy
Under accreditation
What governs this work.
Toxicology operates inside the quality system audited under the certifications listed here.
- OECD GLP
Good Laboratory Practice certification
OECD GLPNGCMA, Department of Science and Technology, Government of India
Compliance with OECD Principles of Good Laboratory Practice, the basis on which study reports are accepted across all OECD Mutual Acceptance of Data countries.
View the certificate
Runs alongside
Nothing here works alone.
Most programmes cross three or four divisions. On one campus, under one quality system, that crossing costs a corridor rather than a shipment.